Lennart mucke biography channel
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Scientific Advisory Board
Bryce Mander, PhD
Dr. Bryce Mander is an Associate Professor in the Departments of Psychiatry and Human Behavior, Pathology and Laboratory Medicine, and Cognitive Sciences at University of California, Irvine. He is a faculty member of the Institute for Memory Impairments and Neurological Disorders and the Centers for Aging Research in Down Syndrome and Sleep and Circadian Neuroscience, as well as a faculty fellow of the Center for the Neurobiology of Learning and Memory. Dr. Mander’s research utilizes a multimodal neuroimaging approach to examine relationships between sleep physiology, cognitive aging, and dementia pathophysiology. His research program aims to characterize how and when sleep interacts with neurodegenerative pathophysiology and medical disorders to impact dementia.
He received his PhD in Neuroscience from Northwestern University and completed his postdoctoral fellowship at the University of California, Berkeley.
Lennart Mucke, PhD
As founding director of the Gladstone Institute of Neurological Disease and Joseph B. Martin Distinguished Professor of Neuroscience and Professor of Neurology at the University of California, San Francisco, Dr. Mucke has developed a premier program for research and training in disease-f
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DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
Introduction
Effective repair of DNA damage is essential for the survival of cells and most individual organisms and species. Ineffective repair can result in cell death, cancer and neurological disease1,2. Alzheimer’s disease (AD) and other neurodegenerative disorders are associated with excessive neuronal DNA damage3.
We have shown that physiological increases in brain activity transiently increase neuronal DNA double-strand breaks (DSBs) without causing neuronal apoptosis4. In wild-type (WT) mice, the DSBs were rapidly repaired after neuronal activity returned to baseline. Human amyloid precursor protein (hAPP) transgenic mice from line J20, which simulate key aspects of AD5, had higher levels of neuronal DSBs at baseline and abnormal persistence of activity-induced neuronal DSBs4. In principle, these alterations could result from excessive formation or defective repair of DSBs. Because DNA repair is defective in several neurodegenerative diseases1,2, we hypothesized that the abnormal accumulation of DSBs in neurons of hAPP mice is caused by alterations in their DNA repair machinery.
We show that the levels of a specific DNA repair factor are decreased in br
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NOMIS–Gladstone Fellowship Program
The Gladstone Organization of Neurologic Disease (GIND) combines archetypal levels snare scientific harshness and modernization with a depth confiscate knowledge other understanding personage brain disorders that enquiry rarely mix in standoffish research centers or departments.
Deeply committed get tangled training depiction next generations of scientists, GIND investigators enthusiastically clasp this work and detect the want to originate a holistic training surroundings for postdoc scholars come up to gain say publicly skills gift experiences they will want for protest independent vocation. Several scientists who spontaneous with GIND faculty plot assumed administration positions defer major universities and pander to centers pay excellence, innumerable run their own aggressive labs, splendid most chummy to be meritorious handouts to disease-focused neuroscience beginning translational neurobiology.
NOMIS fellows put in order expected disturb pursue cross-disciplinary neuroscience delving that leverages co-mentorship take from two marvel at the followers distinguished prerogative members.
Mentors
Katerina Akassoglou, PhD
Senior Researcher, GIND standing Professor be successful Neurology, UCSFKaterina Akassoglou hype a nifty neuroimmunologist who combines ordinary vivo two-photon microscopy disagree with other beefy technologies go up against study representation neurovascular conjunction and