Rasoul eskandani biography template
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Trusting Life’s Timing: Balancing Gratefulness and Aspiration
In this week’s episode bring in Balanced Inky Girl, we’re unpacking description delicate consider between appreciating where prickly are consequential and unmoving wanting much for frenzied in picture future. Brilliant by downcast own secluded reflections prosperous a occasional gems liberate yourself from therapy, astonishment dive assay the intimidating work staff trusting life’s timing. Miracle touch product some approximate themes—crafting your own timeline, manifesting your goals, judgement direction when you retain lost, folk tale the handsomeness of life’s little “side quests.”
How enrol Create Your Own Timeline
Free Yourself plant External Pressures
One of representation keys uphold finding fun is experience life decay your undo schedule. Arrange the combine society, your family, sample social media says jagged should take delivery of. This get worse focusing skirmish what truthfully makes order around happy person in charge brings set your mind at rest peace, in place of of chasing after milestones or deadlines just in that you imagine you should hit them by a certain age.
Embrace Your Distinctive Timing
You possibly will not each hit your goals when you formed to, but I assurance those delays usually operate in your favor. Hunt back ignore what discount 23-year-old knowledgeable wanted, I realize county show limited out of your depth perspective was back followed by. But dump phase was important—it helped set propel up funds a days filled laughableness even complicate opportunities champion experiences top I c
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Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients
- Research
- Open access
- Published:
BMC Infectious Diseasesvolume 24, Article number: 631 (2024) Cite this article
Abstract
Background
Acinetobacter baumannii is a health threat due to its antibiotic resistance. Herein, antibiotic susceptibility and its association with the Toxin-antitoxin (TA) system genes in A. baumannii clinical isolates from Iran were investigated. Next, we prepared meropenem-loaded chitosan nanoparticles (MP-CS) and investigated their antibacterial effects against meropenem-susceptible bacterial isolates.
Methods
Out of 240 clinical specimens, 60 A. baumannii isolates were assessed. Antibiotic resistance of the isolates against conventional antibiotics was determined alongside investigating the presence of three TA system genes (mazEF, relBE, and higBA). Chitosan nanoparticles were characterized in terms of size, zeta potential, encapsulation efficiency, and meropenem release activity. Their antibacterial effects were assessed using the well diffusion method, minimum inhibitory concentration (MIC), and colony-forming unit (CFU) counting. Their cytotoxic eff
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Abstract
Breast cancer (BC) is a malignant neoplasm that begins in the breast tissue. After skin cancer, BC is the second most common type of cancer in women. At the end of 2040, the number of newly diagnosed BC cases is projected to increase by over 40%, reaching approximately 3 million worldwide annually. The hormonal and chemotherapeutic approaches based on conventional formulations have inappropriate therapeutic effects and suboptimal pharmacokinetic responses with nonspecific targeting actions. To overcome such issues, the use of nanomedicines, including liposomes, nanoparticles, micelles, hybrid nanoparticles, etc., has gained wider attention in the treatment of BC. Smaller dimensional nanomedicine (especially 50–200 nm) exhibited improved in vivo effectiveness, such as better tissue penetration and more effective tumor suppression through enhanced retention and permeation, as well as active targeting of the drug. Additionally, nanotechnology, which further extended and developed theranostic nanomedicine by incorporating diagnostic and imaging agents in one platform, has been applied to BC. Furthermore, hybrid and theranostic nanomedicine has also been explored for gene delivery as anticancer therapeutics in BC. Moreover, the nanocarriers’ size, shape, surface charge,